| Holder and Team | Most Passes Attempted, Game |
|---|---|
| Drew Bledsoe, New England vs. Minnesota, Nov. 13, 1994 (OT) | 70 |
| Vinny Testaverde, N.Y. Jets vs. Baltimore, Dec. 24, 2000 | 69 |
| George Blanda, Houston vs. Buffalo, Nov. 1, 1964 | 68 |
| Jon Kitna, Cincinnati vs. Pittsburgh, Dec. 30, 2001 (OT) | 68 |
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