| Holder and Team | Most Passes Had Intercepted, Game |
|---|---|
| Jim Hardy, Chi. Cardinals vs. Philadelphia, Sept. 24, 1950 | 8 |
| Parker Hall, Cleveland vs. Green Bay, Nov. 8, 1942 | 7 |
| Frank Sinkwich, Detroit vs. Green Bay, Oct. 24, 1943 | 7 |
| Bob Waterfield, Los Angeles vs. Green Bay, Oct. 17, 1948 | 7 |
| Zeke Bratkowski, Chicago vs. Baltimore, Oct. 2, 1960 | 7 |
| Tommy Wade, Pittsburgh vs. Philadelphia, Dec. 12, 1965 | 7 |
| Ken Stabler, Oakland vs. Denver, Oct. 16, 1977 | 7 |
| Steve DeBerg, Tampa Bay vs. San Francisco, Sept. 7, 1986 | 7 |
| Ty Detmer, Detroit vs. Cleveland, Sept. 23, 2001 | 7 |
| By many players | 6 |
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