| Holder and Team | Most Touchdown Passes, Game |
|---|---|
| Sid Luckman, Chi. Bears vs. N.Y. Giants, Nov. 14, 1943 | 7 |
| Adrian Burk, Philadelphia vs. Washington, Oct. 17, 1954 | 7 |
| George Blanda, Houston vs. N.Y. Titans, Nov. 19, 1961 | 7 |
| Y.A. Tittle, N.Y. Giants vs. Washington, Oct. 28, 1962 | 7 |
| Joe Kapp, Minnesota vs. Baltimore, Sept. 28, 1969 | 7 |
| By many players. Last time: | 6 |
| Peyton Manning, Indianapolis vs. Detroit, Nov. 25, 2004 | 6 |
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